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KMID : 0942820050040010013
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Journal of Korean Brain Tumor Society
2005 Volume.4 No. 1 p.13 ~ p.20
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High Dose Irradiation Induced IL-1β Expression in the Rat Brain
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Won Gun-Woo
Cho Do-Sang
Kang Shin-Hyuk
Chung Yong-Gu
Kim Han-Kyeom
Kim Chul-Yong
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Abstract
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Objective: Radiotherapy is an important treatment modality for brain tumor, being delivered in conventional fractionated doses or a large single dose as in stereotactic irradiation. However, serious complication such as radiation necrosis can occur and it may be secondary to the expression of acute phase genes, like cytokine. In the present study, we examined the interleukin-1 beta(IL-1β) to clarify the cytokine effect on the radiation-induced brain damage.
Methods: Ninety Sprague-Dawley rats were used and they were classified with irradiation group and sham operation group. After a burr-hole trephination was performed on the right parietal area using a drill, a single 10Gy was irradiated at the ectomy site. Their forebrains were extirpated at 1, 2, 4, 6, and 8 weeks respectively and examined the histopathology and expression of IL-1β. The results were compared with those in sham operation group.
Results: The histologic features were inflammatory cell, vascular proliferation, and congestion in the irradiated hemisphere. They were detected by starting one week after irradiation and necrotic rarefaction was most prominent at eight weeks. The white matter necrosis was also seen in this period. The expression of IL-1ß was markedly elevated in the first week and decreased following the time period.
Conclusions: The present study indicate that expressions of IL-1β are remarkably elevated in the early period after the irradiation to the rat brain. These findings will provide some clue to detect the pathogenesis of the radiation injury.
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KEYWORD
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Radiation damage, Normal rat brain, Interleukin-1 beta
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